I spoke up at work, primarily for the reason to stop my boss from being a bully.  It cost me my job eventually when I decided to leave versus being forced to do everything and anything he felt was appropriate.  He left the Company six months later as the Company I believe had enough of him.  I took a stand and it cost me financially, it made me move out of town (for a new job), and it took me 4 years to recover form the blowback from the Executives and from my former boss.  At his new company he got demoted and now does not manage people.  When you take on a bully, personally or professionally, be ready to do so, it may be the hardest thing you have ever done.  At the end of the day, the bright line is, you are finally bully free and no one can put a price on that :).